Tianeptine Sodium

Tianeptine Sodium is an anxiolytic compound that is primarily used for its mood-boosting and anti-anxiety properties. This substance also has nootropic-like abilities in regards to individuals whose cognition is negatively impacted by mood disorders. It has the ability to improve focus and concentration in individuals who have poor attention spans as well. *Research purpose only.

Recommended Storage: Tianeptine sodium powder is hygroscopic and absorbs air quickly, causing the powder to clump and harden. It is recommended to store it in a cool, dry place, sealed from outside air.  We ship the product in a double sealed bag which can be resealed. Another container is recommended sealing from outside air.

Product Name: Tianeptine sodium

Other Name: Tianeptine sodium salt

CAS: 30123-17-2

M.W: 458.93

M.F: C21H24ClN2NaO4S

Purity: Above 98%

Appearance: Off-white Powder

Packing: 10g/bag; 100g/bag(Aluminum foil bag packaging)

2. Function and Application

Tianeptine sodium is a tricyclic antidepressant TCA in chemistry, but its mode of action is different from the typical TCA.

The main antidepressant effect of Tianeptine sodium is to change the activity of glutamate receptor indirectly, because the release of AMPA receptor, NMDA receptor and BDNF can affect the plasticity of nerve.

Application of tianaptine Stadium

It mainly acts on the 5-HT system, has no excitation, sedation, anti acetylcholine and cardiac toxicity. For depression.

Pharmacological action of tianaptine Stadium

The results also showed that tianeptin was effective on anxiety symptoms, and HAMA score reduction rate was slightly higher than amitriptyline at the 6th weekend, which was consistent with the literature. All in all, the results showed that the antidepressant effect of tianeptine was positive, with less adverse reactions and mild degree. Patients with good drug tolerance, compliance, suitable for clinical application.

Other studies have shown that tianeptine can improve children's asthma. Researchers in Venezuela and the United States reported that tianeptine can suddenly and dramatically improve clinical severe asthma.

The antidepressant mechanism of this product is different from that of traditional TCA, it can increase the uptake of 5-HT in synaptic space, but it has weak effect on 5-HT and Na reuptake. It may have the effect of enhancing 5-HT neuron transmission. There was no affinity for M receptor, H1, α 1 and α 2-NA receptor.

The antidepressant effect of this product is similar to that of TCA, and its safety and tolerance are better than that of TCA (tricyclic antidepressants). The efficacy of this product is similar to that of fluoxetine in SSRI.

The results of animal drug use experiment showed that it can increase the spontaneous activity of pyramidal cells in hippocampus, accelerate the recovery of their function after being inhibited, and increase the reabsorption of 5-hydroxytryptamine by neurons in cerebral cortex and hippocampus.